CONSULTATIONS FOR REJURAN & POLYNUCLEOTIDES
Rejuran® is the brand name of a class of injectable treatments known as 'polynucleotides'. Rejuran is currently the only TGA-approved polynucleotide product available in Australia. Rejuran is not classified as a medicine or an S4 drug and therefore can be discussed explicitly.
Rejuran is very different to other products such as facial volumisers, bio-hydrators, bio-remodellers or bio-stimulators. Dr Jake sometimes refers to Rejuran as a 'bio-regenerator' because it sits in a different category when compared to any other product.
Rejuran contains marine-derived (wild salmon) DNA fragments and these are the so called 'polynucleotides'. Despite what you might have read online, the DNA isn't sourced from salmon sperm but instead it is sourced from the gonad tissue. Rejuran is a clear, colourless and odourless solution which contains polynucleotides or 'PN' for short. The wild salmon used in Rejuran are under the authority of the Korean Fisheries Department and their stocks are maintained and protected. They are not farmed, bred and no hormones or additives are fed to them, leading to the purest polynucleotides in the world.
WHAT ARE POLYNUCLEOTIDES?
Polynucleotides are purified, bio-active DNA fragments. You can think of polynucleotides as 'building blocks' - when these added together in nature they build strands of DNA. Injectable polynucleotides are runny liquids in appearance and feel like a watery-serum to touch.
Rejuran is injected as multiple tiny dots just under the surface of the skin. Immediately after a treatment you will see some prominent and multiple raised dots all over the area of concern. This 'bumpy' look to the skin is very noticeable but only lasts for approximately 24-48 hours. Click here to see what Dr Jake's patient looked like immediately after a forehead and eye treatment
When injected, polynucleotides help stimulate your body's own regenerative and repair mechanisms. Rejuran has been used in Asia since 2014 and over 10 million syringes have been used to date.
HOW DO POLYNUCLEOTIDES WORK?
When injected, polynucleotides signal to the dermis layer of your skin via a number of different cellular pathways. In simple terms, polynucleotides help support your skin's own regenerative capabilities by:
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Stimulating the fibroblast cells to produce more collagen and hyaluronic acid
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Promoting and accelerating skin healing and repair by up-regulating angiogenesis (the formation of new blood vessels) and by down-regulating inflammation (reducing swelling and redness). Clinical studies based on smaller fragments (called polydeoxyribonucleotides or PRDN) have demonstrated impressive results for wound repair, scar remodelling, trauma injuries, burns and diabetic ulcers.
When injected, polynucleotides therefore help to turn on your body's own regenerative and repair mechanisms.
A huge advantage of polynucleotides is that they have never caused a vascular occlusion nor any other significant complications. This means the risk of blindness or stroke (that is associated with fillers) is essentially zero.
Korean doctors with nearly a decade of experience using Rejuran have also noticed how polynucleotides seems help improve issues like sensitive skin and redness. It's therefore also a very useful product when used in combination with laser treatments to improve healing and downtime from these treatments, but also to optimise the overall results. Those who suffer with rosacea or melasma might consider adding Rejuran into their overall skin treatment plan as it may help improve the health of the skin barrier in combination with other treatments.
KEY FEATURES OF REJURAN CONSULTATIONS
Consultations
New patient consultation + Rejuran treatments = 45 mins.
Existing patient consultations + treatments = 30 mins.
Skin quality improvement
Common areas to use Rejuran include the skin around the eyes, the rest of the face and neck. This can improve texture, firmness, crepiness as well as calming inflammation or redness.
How many treatments?
Initially 3 treatments are recommended, 2-4 weeks apart. This is followed by once every 3-6 months for maintenance.
Safety
Rejuran treatments will be visible for approximately 48 hours. Serious complications like vascular occlusions and blindness are not associated with polynucleotides.
REJURAN AREAS
DOWNTIME & AFTER CARE AFTER REJURAN
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Local anaesthetic cream will be applied to the area being treated prior to a treatment. Rejuran does have a moderate sting but this is brief and tolerable.
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Some needle marks or more obvious bruising is common with Rejuran due to the use of a needle. This is especially true around the eye area. Avoiding any non-prescribed blood thinners in the week prior (including fish oils, aspirin and NSAID medications) can help reduce this risk. You can also wear make up the following day to hide any bruising.
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As a result of how Rejuran is injected, you will have multiple visible 'bumps' over the skin area treated. These are self-limiting and will disappear on their own in approximately 48 hours. (If you have thinner or peri-menopausal skin, this may take a day or so longer) Whilst you can go to work or socialise after Rejuran, you might feel a little self-conscious or have people asking what treatment you had done. So these treatments should be planned accordingly if you need to be discrete.